更新日:2019 年 7 月 1 日

フリガナ
オバタ トシオ(OBATA Toshio)
所属学部・学科
健康科学部 看護学科
研究分野
基礎薬理学
研究テーマ
糖尿病心での虚血耐性、フリーラジカル産生と心筋保護作用
取得学位
昭和大学医学博士
所属学会
日本薬理学会 米国神経科学会 日本循環器学会

主な研究業績

年月 研究業績(原著)
Neurosci Lett. 2019; 705: 51-3. Glutaminergic tonic action potentiate MPP+-induced hydroxyl radical production in rat striatum. Obata T.
J. Clin Neurosci. 2019; 63:196-201. The effect of tamoxifen on opening ATP-sensitive K+ channels enhances hydroxyl radical generation in rat rat striatum. Obata T.
J. Osaka Aoyama University. 2018; 1: 1-9. Thyroid hormone-inducible semicarbazide-sensitive amine oxidase (SSAO) in rat brain cytosol. Obata T.
Mathews J Anesthesia. 2017; 1: 1-4 Environmental estrogen-like substances enhances 1-Metyhl-4-Phenylpyridinium ion-induced hydroxyl radical generation in rat striatum. Obata T, Nakashima M.
大阪青山大学看護ジャーナル 創刊号 2017; 1: 59-63. 第 14 回国際毒性学会議(2016;メリダ, メキシコ)に出席して. 小畑 俊男
Eur J Pharmacol. 2017; 774: 1-7. Oxidative stress inactivates ecto-5′-nucleotidase by inhibiting protein kinase C in rat hearts in vivo. Obata T, Nakashima M.
J. Osaka Aoyama University. 2016; 8: 13-8. Inhibition of semicarbazide-sensitive amine oxidase (SSAO) in monkey platelet by various antidepressants drugs. Obata T.
Microvasc Res. 2016; 107:1-5. Fluvastatin, an HMG-CoA reductase inhibitor, facilitate adenosine production in the rat hearts via activation of ecto-5′-nucleotidase. Obata T, Nakashima M.
J Neurol Sci. 2016; 366: 180-3. Opening of ATP-sensitive K+ (KATP) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum. Obata T, Nakashima M.
Indian Heart J. 2016; 871: 25-31. Evidence for existence of thyroid hormone inducible semicarbazide-sensitive amine oxidase (SSAO) in rat heart cytosol. Obata T, Nakashima M.
Eur J Pharmacol. 2016; 774:20-4. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Obata T, Nakashima M.
Eur J Pharmacol. 2013; 700:60-4. Effect of tyramine on the production of interstitial adenosine during perfusion with adenosine 5′-monophosphate in rat hearts in vivo.
Obata T, Miyashita M.
Clin Biochem. 2013;46: 164-6. Protective effect of diltiazem, a L-type calcium channel antagonist, on lysophosphatidylcholine-enhanced hydroxyl radical generation by MPP+ in rat striatum.
Obata T, Miyashita M
Microvasc Res. 2009;77: 163-5. The protective effect of fluvastatin on hydroxyl radical generation by inhibiting low-density lipoprotein (LDL) oxidation in the rat myocardium.
Obata T, Yonemoti H, Aomine M.
Toxicology. 2008;250: 96-9. Protective effect of captopril and enalaprilat, angiotensin- converting enzyme inhibitors, on para-nonylphenol-induced OH generation and dopamine efflux in rat striatum.
Obata T, Takahashi S, Kashiwagi Y, Kubota S.
Life Sci. 2007;80: 1094-9. Absence of tissue-bound semicarbazide-sensitive amine oxidase activity in carp tissues.
Takahashi K, Kakuta I, Sugimoto H, Obata T, Oreland L, Kinemuchi H.
Anal Biochem. 2006; 356:59-65. Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium.
Obata T.
Eur J Pharmacol. 2006; 539:34-8. Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum.
Obata T.
Biochim Biophys Acta. 2006;1760:721-3. Diltiazem, a L-type calcium channel antagonist, suppresses ouabain-enhanced dopamine efflux by 1-methyl-4- phenylpyridinium ion (MPP+) in rat striatum.
Obata T.
J Pharmacol Exp Ther. 2003;305:719-24. Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5′- nucleotidase in rat hearts.
Obata T, Yonemochi H, Arita M.
J Pharmacol Exp Ther. 2001;298:71-6 Histamine increases interstitial adenosine concentration via activation of ecto-5′-nucleotidase in rat hearts in vivo.
Obata T, Kubota S, Yamanaka Y.

その他の業績

年月 業績(総説)
J Cardiol Cardiovasc Med. 2018. 3: 35-48. Microdialysis technique for in-vivo monitoring of OH generation on myocardial injury in the rat. Obata T.
大阪青山大学紀要2016; 8: 19-24. マイクロダイアリシス法のラット心筋への応用(総説). 小畑 俊男
Life Sci. 2006;79: 417-22. Diabetes and semicarbazide-sensitive amine oxidase (SSAO) activity: a review. Obata T.
J Neural Transm. 2006; 113:1131-44. Nitric oxide and MPP+-induced hydroxyl radical generation: a review. Obata T.
J Neural Transm. 2002; 109:1159-80. Dopamine efflux by MPTP and hydroxyl radical generation. Obata T.
Neurochem Res.
2002; 27:423-31.
Environmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: a review. Obata T.
Life Sci.
2002;71: 2083-103.
Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium. Obata T.

職歴

機関名・職名・役職名 就任年月 退任年月
大分医科大学 薬理学 講師 1984.7 2005.3
奥羽大学 薬学部 教授 2005.4 2012.3
四日市看護医療大学 特任教授 2012.4 2014.3
大阪青山大学 特任教授 2014.5 現在に至る

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