更新日：2019 年 7 月 1 日
- フリガナ
- オバタ トシオ（OBATA Toshio）
- 所属学部・学科
- 健康科学部 看護学科
- 研究分野
- 基礎薬理学
- 研究テーマ
- 糖尿病心での虚血耐性、フリーラジカル産生と心筋保護作用
- 取得学位
- 昭和大学医学博士
- 所属学会
- 日本薬理学会 米国神経科学会 日本循環器学会
主な研究業績
| 年月 | 研究業績（原著） |
|---|---|
| Neurosci Lett. 2019; 705: 51-3. | Glutaminergic tonic action potentiate MPP+-induced hydroxyl radical production in rat striatum. Obata T. |
| J. Clin Neurosci. 2019; 63:196-201. | The effect of tamoxifen on opening ATP-sensitive K+ channels enhances hydroxyl radical generation in rat rat striatum. Obata T. |
| J. Osaka Aoyama University. 2018; 1: 1-9. | Thyroid hormone-inducible semicarbazide-sensitive amine oxidase (SSAO) in rat brain cytosol. Obata T. |
| Mathews J Anesthesia. 2017; 1: 1-4 | Environmental estrogen-like substances enhances 1-Metyhl-4-Phenylpyridinium ion-induced hydroxyl radical generation in rat striatum. Obata T, Nakashima M. |
| 大阪青山大学看護ジャーナル 創刊号 2017; 1: 59-63. | 第 14 回国際毒性学会議（2016；メリダ, メキシコ）に出席して. 小畑 俊男 |
| Eur J Pharmacol. 2017; 774: 1-7. | Oxidative stress inactivates ecto-5′-nucleotidase by inhibiting protein kinase C in rat hearts in vivo. Obata T, Nakashima M. |
| J. Osaka Aoyama University. 2016; 8: 13-8. | Inhibition of semicarbazide-sensitive amine oxidase (SSAO) in monkey platelet by various antidepressants drugs. Obata T. |
| Microvasc Res. 2016; 107:1-5. | Fluvastatin, an HMG-CoA reductase inhibitor, facilitate adenosine production in the rat hearts via activation of ecto-5′-nucleotidase. Obata T, Nakashima M. |
| J Neurol Sci. 2016; 366: 180-3. | Opening of ATP-sensitive K+ (KATP) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum. Obata T, Nakashima M. |
| Indian Heart J. 2016; 871: 25-31. | Evidence for existence of thyroid hormone inducible semicarbazide-sensitive amine oxidase (SSAO) in rat heart cytosol. Obata T, Nakashima M. |
| Eur J Pharmacol. 2016; 774:20-4. | Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Obata T, Nakashima M. |
| Eur J Pharmacol. 2013; 700:60-4. | Effect of tyramine on the production of interstitial adenosine during perfusion with adenosine 5′-monophosphate in rat hearts in vivo. Obata T, Miyashita M. |
| Clin Biochem. 2013;46: 164-6. | Protective effect of diltiazem, a L-type calcium channel antagonist, on lysophosphatidylcholine-enhanced hydroxyl radical generation by MPP+ in rat striatum. Obata T, Miyashita M |
| Microvasc Res. 2009;77: 163-5. | The protective effect of fluvastatin on hydroxyl radical generation by inhibiting low-density lipoprotein (LDL) oxidation in the rat myocardium. Obata T, Yonemoti H, Aomine M. |
| Toxicology. 2008;250: 96-9. | Protective effect of captopril and enalaprilat, angiotensin- converting enzyme inhibitors, on para-nonylphenol-induced ・OH generation and dopamine efflux in rat striatum. Obata T, Takahashi S, Kashiwagi Y, Kubota S. |
| Life Sci. 2007;80: 1094-9. | Absence of tissue-bound semicarbazide-sensitive amine oxidase activity in carp tissues. Takahashi K, Kakuta I, Sugimoto H, Obata T, Oreland L, Kinemuchi H. |
| Anal Biochem. 2006; 356:59-65. | Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium. Obata T. |
| Eur J Pharmacol. 2006; 539:34-8. | Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum. Obata T. |
| Biochim Biophys Acta. 2006;1760:721-3. | Diltiazem, a L-type calcium channel antagonist, suppresses ouabain-enhanced dopamine efflux by 1-methyl-4- phenylpyridinium ion (MPP+) in rat striatum. Obata T. |
| J Pharmacol Exp Ther. 2003;305:719-24. | Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5′- nucleotidase in rat hearts. Obata T, Yonemochi H, Arita M. |
| J Pharmacol Exp Ther. 2001;298:71-6 | Histamine increases interstitial adenosine concentration via activation of ecto-5′-nucleotidase in rat hearts in vivo. Obata T, Kubota S, Yamanaka Y. |
その他の業績
| 年月 | 業績（総説） |
|---|---|
| J Cardiol Cardiovasc Med. 2018. 3: 35-48. | Microdialysis technique for in-vivo monitoring of OH generation on myocardial injury in the rat. Obata T. |
| 大阪青山大学紀要2016; 8: 19-24. | マイクロダイアリシス法のラット心筋への応用（総説）. 小畑 俊男 |
| Life Sci. 2006;79: 417-22. | Diabetes and semicarbazide-sensitive amine oxidase (SSAO) activity: a review. Obata T. |
| J Neural Transm. 2006; 113:1131-44. | Nitric oxide and MPP+-induced hydroxyl radical generation: a review. Obata T. |
| J Neural Transm. 2002; 109:1159-80. | Dopamine efflux by MPTP and hydroxyl radical generation. Obata T. |
| Neurochem Res. 2002; 27:423-31. |
Environmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: a review. Obata T. |
| Life Sci. 2002;71: 2083-103. |
Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium. Obata T. |
職歴
| 機関名・職名・役職名 | 就任年月 | 退任年月 |
|---|---|---|
| 大分医科大学 薬理学 講師 | 1984.7 | 2005.3 |
| 奥羽大学 薬学部 教授 | 2005.4 | 2012.3 |
| 四日市看護医療大学 特任教授 | 2012.4 | 2014.3 |
| 大阪青山大学 特任教授 | 2014.5 | 現在に至る |
