小畑 俊男

更新日:2015年5月7日

フリガナ
オバタ トシオ(Obata  Toshio)
所属学部・学科
健康科学部 看護学科
研究分野
基礎薬理学
研究テーマ
糖尿病心での虚血耐性、フリーラジカル産生と心筋保護作用
取得学位
昭和大学医学博士
所属学会
日本薬理学会 米国神経科学会 日本循環器学会

主な研究業績(発行又は発表年月)

年 月 研 究 業 績 (原 著)
Eur J Pharmacol. 2013; 700:60-4. Effect of tyramine on the production of interstitial adenosine during perfusion with adenosine 5′-monophosphate in rat hearts in vivo.
Obata T, Miyashita M.
Clin Biochem. 2013;46: 164-6. Protective effect of diltiazem, a L-type calcium channel antagonist, on lysophosphatidylcholine-enhanced hydroxyl radical generation by MPP+ in rat striatum.
Obata T, Miyashita M
Microvasc Res. 2009;77: 163-5. The protective effect of fluvastatin on hydroxyl radical generation by inhibiting low-density lipoprotein (LDL) oxidation in the rat myocardium.
Obata T, Yonemoti H, Aomine M.
Toxicology. 2008;250: 96-9. Protective effect of captopril and enalaprilat, angiotensin- converting enzyme inhibitors, on para-nonylphenol-induced OH generation and dopamine efflux in rat striatum.
Obata T, Takahashi S, Kashiwagi Y, Kubota S.
Life Sci. 2007;80: 1094-9. Absence of tissue-bound semicarbazide-sensitive amine oxidase activity in carp tissues.
Takahashi K, Kakuta I, Sugimoto H, Obata T, Oreland L, Kinemuchi H.
Anal Biochem. 2006; 356:59-65. Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium.
Obata T.
Eur J Pharmacol. 2006; 539:34-8. Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum.
Obata T.
Biochim Biophys Acta. 2006;1760:721-3. Diltiazem, a L-type calcium channel antagonist, suppresses ouabain-enhanced dopamine efflux by 1-methyl-4- phenylpyridinium ion (MPP+) in rat striatum.
Obata T.
J Pharmacol Exp Ther. 2003;305:719-24. Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5′- nucleotidase in rat hearts.
Obata T, Yonemochi H, Arita M.
J Pharmacol Exp Ther.  2001;298:71-6 Histamine increases interstitial adenosine concentration via activation of ecto-5′-nucleotidase in rat hearts in vivo.
Obata T, Kubota S, Yamanaka Y.

 

その他の業績

年 月 業 績 (総 説)
Life Sci. 2006;79: 417-22. Diabetes and semicarbazide-sensitive amine oxidase (SSAO) activity: a review. Obata T.
J Neural Transm. 2006; 113:1131-44. Nitric oxide and MPP+-induced hydroxyl radical generation: a review. Obata T.
J Neural Transm. 2002; 109:1159-80. Dopamine efflux by MPTP and hydroxyl radical generation. Obata T.
Neurochem Res.
2002; 27:423-31.
Environmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: a review. Obata T.
Life Sci.
2002;71: 2083-103.
Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium. Obata T.

職歴(西暦)

機関名・職名・役職名 就任年月 退任年月
大分医科大学 薬理学 講師 1984.7 2005.3
奥羽大学 薬学部 教授 2005.4 2012.3
四日市看護医療大学 特任教授 2012.4 2014.3
大阪青山大学 特任教授 2014.5  現在に至る

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